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The cerebral cortex, the convoluted "grey matter" that makes up 80% of the human brain, is responsible for our ability to remember, think, reflect, empathize, communicate, adapt to new situations and plan for the future. The cortex first appeared in mammals, and it has a fundamentally simple repetitive structure that is the same across all mammalian species.

The brain is populated with billions of neurons, each connected to thousands of its neighbors by dendrites and axons, a kind of biological "wiring". The brain processes information by sending electrical signals from neuron to neuron along these wires. In the cortex, neurons are organized into basic functional units, cylindrical volumes 0.5 mm wide by 2 mm high, each containing about 10,000 neurons that are connected in an intricate but consistent way. These units operate much like microcircuits in a computer. This microcircuit, known as the neocortical column (NCC), is repeated millions of times across the cortex. The difference between the brain of a mouse and the brain of a human is basically just volume - humans have many more neocortical columns and thus neurons than mice.

This structure lends itself to a systematic modeling approach. And indeed, the first step of the Blue Brain project is to re-create this fundamental microcircuit, down to the level of biologically accurate individual neurons. The microcircuit can then be used in simulations.

For an in-depth view of the project, read Henry Markram's Perspectives article in the February 2006 issue of Nature Reviews Neuroscience.

What the Blue Brain Project is not

The Blue Brain Project is an attempt to reverse engineer the brain, to explore how it functions and to serve as a tool for neuroscientists and medical researchers. It is not an attempt to create a brain. It is not an artificial intelligence project. Although we may one day achieve insights into the basic nature of intelligence and consciousness using this tool, the Blue Brain Project is focused on creating a physiological simulation for biomedical applications.