Neuroinformatics - Laboratory for the Neural Basis of Brain States

Bas-Jan Zandt is a Post Doc in the Laboratory for the Neural Basis of Brain States within the Neuroinformatics Division.

At Blue Brain he aims to investigate through which mechanisms certain genetic mutations in ion channels cause epilepsy. His investigation creates models of healthy and mutated ion channels, and examines how the neural dynamics of single cells and network change when mutations are introduced.

Before joining Blue Brain, Bas-Jan was a post-doc in Bergen, Norway, where he created detailed computer models of retinal AII amacrine cells using electrophysiological recordings and multi-photon microscopy.

It was during his PhD, that he became interested in mathematical and computational neuroscience and his PhD thesis discusses how ion concentrations in the brain are affected by lack of oxygen and how this changes single neuron activity and brain rhythms.

Jan has a Bachelor of Science and Master of Science in Applied Physics from the University of Twente, in the Netherlands.

In his free time, Bas-Jan likes to go ballroom dancing, take part in martial arts, and go swimming or hiking in the mountains with his wife and two sons.

Selected Publications

Neural Dynamics during Anoxia and the Wave of Death
Bas-Jan Zandt, Bennie ten Haken, Gert van Dijk, Michel JAM van Putten (2011)
PLOS ONE, 6(7):e22127. doi:10.1371/journal.pone.0022127

Diffusing substances during spreading depolarization: analytical expressions for propagation speed, triggering and concentration time-courses
Bas-Jan Zandt, Bennie ten Haken, Michel J.A.M. van Putten (2013)
Journal of Neuroscience, 33(14):59155923

A neural mass model based on single cell dynamics to model pathophysiology
Bas-Jan Zandt, Sid Visser, Michel J.A.M. van Putten, Bennie ten Haken (2014)
Journal of computational neuroscience 37 (3), 549-568

How does spreading depression spread? - Physiology and modelling
Bas-Jan Zandt, Bennie ten Haken, Michel JAM van Putten, Markus Dahlem (2015)
Reviews in the neurosciences 26 (2), 183-198

AII amacrine cells: Quantitative reconstruction and morphometric analysis of electro- physiologically identified cells in rat retinal slices imaged with multi-photon excitation microscopy.
Bas-Jan Zandt, Jian Hao Liu, Margaret Lin Veruki, Espen Hartveit (2016)
Brain Structure and Function, Jan;222(1):151-182

Full list of publications are available here: https://www.researchgate.net/profile/Bas-Jan_Zandt